Impact of Periodontal Therapy on Systemic Inflammation and Renal Function in Chronic Kidney Disease: A Secondary Cohort Analysis
Impact of Periodontal Therapy on Systemic Inflammation
Keywords:
Periodontal Therapy, Chronic Kidney Disease, Systemic Inflammation, Renal Function, Scaling and Root PlaningAbstract
Background: Periodontal disease is a preventable inflammatory load; however, there is a lack of evidence that support the therapeutic effects of periodontal disease after periodontal intervention in CKD individuals. The proposed secondary analysis is focused on assessing the impact of non-surgical periodontal therapy on the functions of the kidneys and inflammatory markers in the human system in patients with CKD. Methods: The secondary cohort study was based on a retrospective study of CKD patients with past periodontal disease case. The therapeutic evaluation involved forty patients which underwent scaling and root planing (SRP). Parameters of renal function (estimated glomerular filtration rate (eGFR), serum creatinine), systemic inflammatory [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and periodontal clinical were evaluated in preintervention and postintervention (3 months) time. Results: After completion of periodontal therapy, there was a significant increase in the renal function, as the mean eGFR improved significantly with a value of 42.3 ± 8.6 to 48.7 ± 7.9 mL/min/1.73 m 2 (p = 0.031) and serum creatinine declined to 2.1 ± 0.5 to 1.8 ± 0.4 mg/dL (p = 0.028). The level of systemic inflammation decreased from 6.1 ± 1.8 to 4.3 ± 1.4 mg/L (p = 0.019) of CRP, IL-6 from 5.4 ± 1.5 to 3.7 ± 1.2 pg/mL (p = 0.014), TNF-α from 6.8 ± 2.2 to 4.5 ± 1.9 pg/mL (p = 0.022). Conclusion: Increased systemic inflammation is significantly decreased by non-surgical periodontal therapy and it improves renal functioning in patients with CKD.
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Copyright (c) 2025 Amna Ehsan, Muneeba Ashraf, Muhammad Ikram, Kanwal Ehsan (Author)
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